Hypoaggregability of washed platelets from stroke-prone spontaneously hypertensive rats (SHRSP).
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Hypoaggregability of washed platelets from stroke-prone spontaneously hypertensive rats (SHRSP).
The aggregation properties of washed SHRSP platelets were investigated in comparison with normotensive WKY platelets at prehypertensive (4 weeks), early hypertensive (11 weeks) and late hypertensive (17 weeks) ages in the absence of plasma factors. The number of platelets in SHRSP was markedly lower with the development of hypertension than that in WKY. The thrombin- and collagen-induced aggreg...
متن کاملPlatelet survival studies in stroke-prone spontaneously hypertensive rats (SHRSP).
Platelet survival was studied by using 51Cr-labeled platelets in stroke-prone spontaneously hypertensive rats (SHRSP), stroke-resistant SHR (SHRSR) and normotensive control rats of the Wistar-Kyoto (WK) strain. Relatively young animals of the same age prior to the development of cerebrovascular lesions (cerebral infarction and/or hemorrhage) were used. Platelet half-life time in SHRSP was sligh...
متن کاملStroke-Prone Spontaneously Hypertensive Rats
Background and Purpose We examined metabolic and functional changes when forebrain ischemia was induced in strokeprone spontaneously hypertensive rats by bilateral carotid artery occlusion. In addition, the protective effect of clentiazem was evaluated in this model. Methods Rats were anesthetized with urethane. Cerebral blood flow was measured with a laser Doppler fkrwmeter. Cerebral high-ener...
متن کاملProtective Effects of Japanese Soybean Paste (Miso) on Stroke in Stroke-Prone Spontaneously Hypertensive Rats (SHRSP).
BACKGROUND AND HYPOSESIS Soybean isoflavones have been shown to reduce the risk of cerebral infarction in humans according to epidemiological studies. However, whether intake of miso can reduce the incidence of stroke in animal models remains unknown. In this study, we investigated the effects of soybean paste (miso) in an animal model of stroke. METHODS Stroke-prone spontaneously hypertensiv...
متن کاملDorsal cerebral collaterals of stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar Kyoto rats (WKY).
Earlier studies established that stroke-prone spontaneously hypertensive rats (SHRSP) invariably infarct after middle cerebral artery (MCA) occlusion. Normotensive rats are usually protected from infarction after the occlusion. Objectives of this study were to characterize the anastomosing collaterals that may determine the different outcomes to MCA occlusion in SHRSP and Wistar Kyoto rats (WKY...
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ژورنال
عنوان ژورنال: Stroke
سال: 1984
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.15.1.70